解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
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综合和补充性医学
医学伦理学
医学信息学
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医学,全科和内科
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产科医学和妇科医学
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生理学
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热带医学
泌尿学和肾脏学
病毒学
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健康政策和服务
心理学,临床
abstract:BACKGROUND:Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in pa...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-42
更新日期:2013-06-03 00:00:00
abstract:BACKGROUND:Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H215O (or C15O2) can quantify CBF and apply kinetic analyses, including autoradiography (ARG) and the basis function methods (BFM). These approache...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-41
更新日期:2013-05-23 00:00:00
abstract::Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-36
更新日期:2013-05-08 00:00:00
abstract:BACKGROUND:[11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by optimizing the timing of initiation of the scan and applying correction to the plasma concentrati...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-27
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-12
更新日期:2013-02-25 00:00:00
abstract:UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-7
更新日期:2013-01-31 00:00:00
abstract:UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-55
更新日期:2012-09-29 00:00:00
abstract:UNLABELLED: BACKGROUND:An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-48
更新日期:2012-09-21 00:00:00
abstract:BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-41
更新日期:2012-07-23 00:00:00
abstract:BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-35
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-26
更新日期:2012-06-09 00:00:00
abstract:BACKGROUND:To assess 18-fluorodeoxyglucose (FDG) bowel uptake in patients with differentiated thyroid cancer (DTC) treated with sorafenib. FINDINGS:Visual (5-point scale) and high maximum standard uptake value (SUVmax) semi-quantitative analyses were conducted in 63 positron emission tomography (PET) studies performed...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-18
更新日期:2012-05-07 00:00:00
abstract:BACKGROUND:Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-7
更新日期:2012-02-13 00:00:00
abstract:BACKGROUND:Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targetin...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-1-19
更新日期:2011-08-26 00:00:00
abstract:: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-1-9
更新日期:2011-07-26 00:00:00